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KMID : 1161520190230020112
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Animal Cells and Systems
2019 Volume.23 No. 2 p.112 ~ p.117
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VNN3 is a potential novel biomarker for predicting prognosis in clear cell renal cell carcinoma
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Ha Mi-Hyang
Jeong Ho-Im
Roh Jong-Seong
Lee Beom-Gu
Lee Dong-Jun
Han Myoung-Eun
Oh Sae-Ock
Sohn Dong-Hyun
Kim Yun-Hak
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Abstract
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Although pathological observations provide approximate prognoses, it is difficult to achieve prognosis in patients with existing prognostic factors. Therefore, it is very important to find appropriate biomarkers to achieve accurate cancer prognosis. Renal cell carcinoma (RCC) has several subtypes, the discrimination of which is crucial for proper treatment. Here, we present a novel biomarker, VNN3, which is used to prognose clear cell renal cell carcinoma (ccRCC), the most common and aggressive subtype of kidney cancer. Patient information analyzed in our study was extracted from The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) cohorts. VNN3 expression was considerably higher in stages III and IV than in stages I and II. Moreover, Kaplan?Meier curves associated high VNN3 expression with poor prognoses (TCGA, p?
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KEYWORD
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VNN3, biomarker, clear cell renal cell carcinoma, TCGA, ICGC
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